Publications

1. Nargund S, Mauch K. 2020. Hybrid Models for Biopharmaceutical Process Development – Making the Best of Mechanistic Know-How and Data-Driven Insights. read article
2. Nargund S, Guenther K, Mauch K. 2019. The Move toward Biopharma 4.0: Insilico Biotechnology develops “smart” processes that benefit biomanufacturing through Digital Twins. Genetic Engineering & Biotechnology News 39 (6), 53-55. read article
3. Barbosa S, Niebel B, Wolf S, Mauch K, Takors R. 2018. A guide to gene regulatory network inference for obtaining predictive solutions: Underlying assumptions and fundamental biological and data constraints. Biosystems 174:37-48. read article
4. Popp O, Müller D, Didzus K, Paul W, Lipsmeier F, Kirchner F, Niklas J, Mauch K, Beaucamp N. 2016. A hybrid approach identifies metabolic signatures of high-producers for chinese hamster ovary clone selection and process optimization. Biotechnology and Bioengineering 113(9). read article
5. Boi FY, Diaz Ochoa JG, Gajewska M, Kovarich S, Mauch K, Paini A, Péry A, Vicente J, Benito S, Tenga S, Worth A. 2016. Multiscale modelling approaches for assessing cosmetic ingredients safety. Toxiciology. 361. read article
6. Villaverde AF,Bongard S,Mauch K, Balsa-Canto E, Banga JR. 2016. Metabolic engineering with multi-objective optimization of kinetic models. Journal of Biotechnology 222: 1–8. read article
7. Villaverde AF, Bongard S, Mauch K, Müller D, Balsa-Canto E, Schmid J, Banga J. 2015. A Consensus Approach for Estimating the Predictive Accuracy of Dynamic Models in Biology. Computer Methods and Programs in Biomedicine 119 (1): 17-28. read article
8. Villaverde AF, Henriques D, Smallbone K, Bongard S, Schmid J, Cicin-Sain D, Crombach A, Saez-Rodriguez J, Mauch K, Balsa-Canto E, Mendes P, Jaeger J, Banga J. 2015. BioPreDyn-bench: A Suite of Benchmark Problems for Kinetic Modelling in Systems Biology. BMC Systems Biology 9. read article
9. Ryll A, Bucher J, Bonin A, Bongard S, Gonçalves E, Saez-Rodriguez J, Niklas J, Klamt SA. 2014. A Model Integration Approach Linking Signalling and Gene-Regulatory Logic with Kinetic Metabolic Models. Biosystems 124: 26-38. read article
10. Villaverde AF, Bongard S, Mauch K, Müller D, Balsa-Canto E, Schmid J, Banga J. 2014. High-Confidence Predictions in Systems Biology Dynamic Models. In 8th International Conference on Practical Applications of Computational Biology & Bioinformatics (PACBB 2014), ed. by Julio Saez-Rodriguez, Miguel P. Rocha, Florentino Fdez-Riverola, and Juan F. De Paz Santana. Advances in Intelligent Systems and Computing 294: 161–171. Springer International Publishing. read article
11. Wahrheit J, Niklas J, Heinzle E. 2014. Metabolic Control at the Cytosol–Mitochondria Interface in Different Growth Phases of CHO Cells. Metabolic Engineering 23: 9-21. read article
12. Vieira Gonçalves EJ, Bucher J, Ryll A, Niklas J, Mauch K, Klamt S, Rocha M, Saez-Rodriguez J. 2013. Bridging the Layers: Towards Integration of Signal Transduction, Regulation and Metabolism into Mathematical Models. Molecular BioSystems 9: 1576–1583. read article
13. Müller D, Kirchner F ,Mangin S, Niklas J, Mauch K. 2012. Accelerating Biopharma Process Design. Genetic Engineering & Biotechnology News 32 (2): 40–41. read article
14. Müller D, Kirchner F, Mangin S, Mauch K. 2011. Accelerating Process Development Through Analysis of Cell Metabolism. BMC Proceedings 5 Suppl 8: P81. read article
15. Niklas J, Heinzle E. 2011. Metabolic Flux Analysis in Systems Biology of Mammalian Cells. Advances in Biochemical Engineering/Biotechnology. read article
16. Maier K, Hofmann U, Reuss M, Mauch K. 2010. Dynamics and Control of the Central Carbon Metabolism in Hepatoma Cells. BMC Syst Biol 4: 54. read article
17. Niklas J, Schneider K, Heinzle E. 2010. Metabolic Flux Analysis in Eukaryotes. Current Opinion in Biotechnology 21 (1): 63–69. read article
18. Maier K, Hofmann U, Reuss M, Mauch K. 2008. Identification of Metabolic Fluxes in Hepatic Cells from Transient 13C-labeling Experiments: Part II. Flux Estimation. Biotechnol Bioeng 100 (2): 355–70. read article
19. Schmalzriedt S, Jenne M, Mauch K, Reuss M. 2003. Integration of Physiology and Fluid Dynamics. Adv Biochem Eng Biotechnol 80: 19–68. read article
20. Chassagnole C, Noisommit-Rizzi N, Schmid JW, Mauch K, Reuss M. 2002. Dynamic Modeling of the Central Carbon Metabolism of Escherichia Coli. Biotechnol Bioeng 79 (1): 53–73. read article